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Gut inflammation and barrier dysfunction may facilitate -synuclein misfolding in the enteric nervous system, with retrograde propagation via the vagus nerve ( Probiotics, prebiotics, and synbiotics are under clinical investigation as adjunct therapies to modulate gut-brain interactions and reduce systemic inflammation ( 5 Treatment challenges and therapeutic innovations Despite being the cornerstone of symptomatic management, current Parkinsons disease (PD) treatments are palliative rather than disease-modifying

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